Nasal immunization with homogenate and peptide antigens induces protective immunity against Trichinella spiralis.

نویسندگان

  • Carolann McGuire
  • Weng C Chan
  • Derek Wakelin
چکیده

Mice were successfully immunized against the intestinal nematode Trichinella spiralis by intranasal administration of a 30-mer peptide antigen with cholera toxin B. Immunized mice developed antigen-specific serum immunoglobulin G1, intestinal immunoglobulin A, and a type 2-biased cytokine response. Intranasal immunization therefore generates the Th2-mediated responses required for immunity against intestinal parasites.

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عنوان ژورنال:
  • Infection and immunity

دوره 70 12  شماره 

صفحات  -

تاریخ انتشار 2002